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A key supporting study was retracted due to data fabrication, and the related prodrug fosgonimeton saw adverse events in clinical trials

247 In another trial, patients with type 2 diabetes who also had mild-to-moderate symptoms of anxiety and depression received either 30 mg saffron extract or placebo daily for eight weeks

The mechanism of action has not been fully elucidated, but it is thought that GHK-Cu may promote fibroblast proliferation resulting in collagen synthesis which may in turn promote increased scalp health and blood flow to hair follicles

Pharmaceuticals, 18(2), 185.

The bulk of these side effects impact the GI system, where GLP-1 RAs work to slow down gastric emptying